Jun 18, 2021Liked by Harvard2TheBigHouse

H2BH -- have read your articles for the last year and appreciate your ongoing attempts to break things down critically. So let me ask a question as I'm curious what your view is....

This is the first time I've read an argument that COVID is a de-attenuating virus. So I'm curious how you reconcile this theory with suggestive evidence that fatality of the virus was higher in the past and then the circumstantial evidence the virus targeted women more virulently than men early on.

By the former I mean more than the early videos of people collapsing in the street, but also projections of the mortality rate as somewhere in the 1-2% range based on cases like the Diamond Princess. On the latter, there is the rumour that one of the earliest researchers to die was a young women, and then the suggestion from the Washington Post (?) that one of the early fatalities was the wife of one of the three WIV researchers who got sick. But now men are affected disproportionately it seems.

Wondering if you have any thoughts. How can a de-attenuating virus be both increasing infectiousness and danger and yet also losing those properties relatively quickly? What am I missing here?

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Jun 2, 2021Liked by Harvard2TheBigHouse

I will never forget reading your first article in Sars-cov19 and thinking you are onto something. Here we are today and you were right all along. I guess the next question is the big one. Why was gain of function funding continued, the players involved, how was the virus released and why and who is profiting from this. Frightening.

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Jan 7, 2022·edited Jan 7, 2022Liked by Harvard2TheBigHouse

Couple of questions... Is it possible to predict (it is really a look backwards into its history, to which it is returning by deattenuation), what will it revert to?

Also, do you think that a hypothesis that Omicron is lab made, is based on strong evidence, weak evidence, or is false?

I recall a video of Peter Dazchak discussing "modeling" of what changes are likely to happen once a virus is in circulation, how realistic is this?

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Sep 28, 2021Liked by Harvard2TheBigHouse

So, what is/was it de-attenuating to? Is it a worse virus or is/was it getting milder, well, milder before I suppose we applied evolutionary pressure via lockdowns and social distancing, and then deployed a Gain of Function serial passage experiment disguised as a vaccine.

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Feb 28, 2022·edited Feb 28, 2022

Hi Dan,

Could you please confirm if the omicron theory below is true? Thanks!

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7568239/ Superantigenic character of an insert unique to SARS-CoV-2 spike supported by skewed TCR repertoire in patients with hyperinflammation Sept. 2020

"The binding epitope on S harbors a sequence motif unique to SARS-CoV-2 (not present in other SARS-related coronaviruses), which is highly similar in both sequence and structure to the bacterial superantigen staphylococcal enterotoxin B."

https://www.cell.com/structure/fulltext/S0969-2126(21)00121-0?_returnURL=https%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS0969212621001210%3Fshowall%3Dtrue A monoclonal antibody against staphylococcal enterotoxin B superantigen inhibits SARS-CoV-2 entry in vitro April 2021

https://www.reddit.com/r/cvnews/comments/rdtb0c/omicron_529_staphylococcus_enterotoxin_b_is_a/ "Now look at Omicron spike protein 671-692. Two amino acid changes and one is the infamous proline change near the FCS. Prolines are right angle brackets in proteins. When they change, they alter structure. P681H N679K This may attenuate the SEB toxicity. Fewer Cytokine storms."

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